Effects of a potent and selective PPAR-[alpha] agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: Two randomized controlled trials
Article Abstract:
Two randomized controlled trials were conducted to examine the safety and efficacy of LY518674, a peroxisome proliferator-activated receptor-[alpha] agonist. The results of the pair of trials demonstrated that in patients with dyslipidemia, LY518674 and fenofibrate decreased triglycerides and increased high-density lipoprotein cholesterol, but also increased serum creatinine.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
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Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk
Article Abstract:
A study to determine the connection between genetic and biochemical determinants and the risk of cardiovascular disease in humans was conducted. Results showed that paraoxonase 1 activity and genetic determinants played a direct role in raising the risk of cardiovascular disease.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2008
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Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus
Article Abstract:
The study evaluates pioglitazone drug used in patients with Type 2 Diabetes Mellitus and its effects on cardiovascular events by clinical trials. There is a mixed result of reducing the risk of cardiovascular ischemic complications.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
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